Heme modulation involves the regulation of heme, a molecule that plays a crucial role in various biological processes such as oxygen transport, energy production, and enzymatic reactions. Research in this area focuses on understanding how heme levels and distribution are controlled within cells and tissues, as well as how heme-binding proteins and enzymes are regulated. Alterations in heme modulation have been associated with a range of diseases, including anemia, cancer, and neurodegenerative disorders. Studying heme modulation can provide insights into cellular function and potential therapeutic targets for treating heme-related disorders.